Anatomy, Histologyو Embryology
Behrooz Yahyaei; Neda Sheikh Mohammadi
Volume 28, Issue 6 , January and February 2022, , Pages 979-981
Abstract
Background: Due to the effect of L-arginine analogues on inhibiting nitric oxide synthesis and exercise training as one of the non-pharmacological methods, the aim of this study was to evaluate the effect of aerobic exercise training with garlic extract on changes of cerebellar tissue in rats with induced ...
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Background: Due to the effect of L-arginine analogues on inhibiting nitric oxide synthesis and exercise training as one of the non-pharmacological methods, the aim of this study was to evaluate the effect of aerobic exercise training with garlic extract on changes of cerebellar tissue in rats with induced hypertension.Materials & Methods: Rats weighing 200 to 220 gr and hypertension at 10 to 12 weeks of age responding to the main symptoms of hypertension were selected. The rats will be divided into 6 treatment groups after a period of injection of L_NAME that results in hypertension. Balance and motor coordination test was performed after 8 weeks of exercise using Beam Walking Test. The treatment groups were given orally garlic and sorbide extracting.Results: In the hypertensive group, white matter and gray matter had some amount of hypertension associated with cellular distribution in the granular area. In Purkinje cells, degenerative cellular changes are observed.Endurance training group did not show any significant changes compared to control group. The endurance training group and the garlic extract retained some meningeal detachment along with some blood accumulation, and the sorbide group in the purkinje cells degenerative changes such as bold cytoplasm and unspecified nucleus are seen.Conclusion: Hypertension causes moderate changes in the purkinje layer and mild changes in the granular layer, as well as mild hyperemia in the cerebellar tissue and the sorbide and garlic extract alone, as well as markedly reduced exercise training.